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KMID : 0603519990040010001
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 1 p.1 ~ p.8
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A Study on the Analysis of a New Broad Spectrum Tumor-Marker (GIFTEC Reagent)
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Son Han-Chul
Bae Young-Tae
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Abstract
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The GIFTEC test is a very convenient test to detect the cancer within 30 minutes by using random urine specimens of various types of cancer. This new marker is appropriate for cancer screening. However, some problems have been pointed out, such as the high rate of false positive reaction by benign diseases, low sensitivity and unelucidated reaction material. The pupose of this study is to analysis the reaction material by fractionation and examine the clinical usefulness of the GIFTEC test, as compared with the usefulness of the polyamine test The salting-out process was conducted with 10% and 20% ammoium sulfate, and gel filteration was conducted with Sephacryl S100 with the low pressure pump to compare changes in elusion pattern. Then, the GREC test was taken with the GIFTEC kit, simultaneously with the polyamine test with the enzyme immunoassay. Pellet was not separated with the ammonium sulfate. But after the gel filteration, the specificity and diagnostic efficiency of the GIFTEC test rose from 80.2% to 97.1%, and from 79.6% to 94.5%, respectively, though its sensitivity remained at 65.6%. As a result, its false positive rate could be lowered and its diagnosibility could be raised. The diagnostic efficency of the GIFTEC test was superior when used in combination with the polyamine test. The GIFTEC test after gel filteration has higher diagnostic efficiency and lower false positive reaction rate, and it has been found to be more useful than the polyamine test. Thus the GIPTEC test can be a useful tool for screening early cancers due to its advantages like rapidity, simplicity, low cost and use of random urine. If used in the form of combination assay with the polyamine test, the GIPTEC will be particularly useful in discriminating the normal group from the high risk group.
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KEYWORD
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Fraction, Gel filteration, GIPTEC test, Polyamine test
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